degree in Biochemistry from Columbia University. degree in Biochemistry from Harvard University, and a Ph.D. degree in Chemistry from Barnard College, an M.A. Levin is currently Head, Section on Viral Gene Regulation in the Program on Genomics of Differentiation, NICHD. In other studies, our efforts are directed toward understanding the function of the viral capsid protein (CA) in HIV-1 assembly and early postentry events during the course of virus replication in vivo.ĭr. We are also investigating the mechanism of antiviral activity of two human cytidine deaminases, APOBEC3G (A3G) and APOBEC3A (A3A). Much of our work focuses on the viral nucleocapsid protein (NC), a nucleic acid chaperone that remodels nucleic acid structures so that the most thermodynamically stable conformations are formed-an activity that is critical for highly efficient and specific viral DNA synthesis. To investigate the individual steps in HIV-1 reverse transcription, a major target of HIV therapy, we have developed reconstituted model systems. These studies are critical for developing new strategies to combat the AIDS epidemic, which continues to be a global threat to human health. The goal of the research performed in the Section on Viral Gene Regulation is to define the molecular mechanisms responsible for the replication of HIV and related retroviruses and to investigate the role of host proteins that block virus infection. Molecular Genetics of Mammalian Retrovirus Replication
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